Research Articles
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Walunj, D., Egarmina, K., Zipin-Roitman, A., Muddineni, S.S.N.A., Tkachenko, I., Mitra, P., Tobi, D., Bazylevich, A., Shpilberg, O., Milyavsky, M. and Hershkovitz-Rokah, O., 2025. Novel dual action chimera doxorubizen demonstrates superior efficacy to doxorubicin in acute leukemia. Scientific Reports, 15(1), p.10607.
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Rall-Scharpf, M., Schlotter, D., Koch, P., Szafranski, K., Groth, M., Sahm, A., Biber, S., Castaño, B.A., Heitmeir, B., Zengerling, F. and Deniz, M., 2025. Replication stress responses in human lymphocytes change sex-specifically during aging. Nucleic Acids Research, 53(11), p.gkaf498.
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Kugler, E., Madiwale, S., Yong, D., Thoms, J.A., Birger, Y., Sykes, D.B., Schmoellerl, J., Drakul, A., Priebe, V., Yassin, M. and Aqaqe, N., 2023. The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG. Nature communications, 14(1), p.5871.
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Rasoulouniriana, D., Santana-Magal, N., Gutwillig, A., Farhat-Younis, L., Tal, L., Amar, S., Milyavsky, M., Muddineni, S.S.N.A., Solomon, N., Shpilt, H. and Dotan, S., 2023. T cells expressing a modified fcγRI exert antibody-dependent cytotoxicity and overcome the limitations of CAR T-cell therapy against solid tumors. Cancer Immunology Research, 11(6), pp.792-809.
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Boila, L.D., Ghosh, S., Bandyopadhyay, S.K., Jin, L., Murison, A., Zeng, A.G., Shaikh, W., Bhowmik, S., Muddineni, S.S.N.A., Biswas, M. and Sinha, S., 2023. KDM6 demethylases integrate DNA repair gene regulation and loss of KDM6A sensitizes human acute myeloid leukemia to PARP and BCL2 inhibition. Leukemia, 37(4), pp.751-764.
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Feldman, T., Bercovich, A., Moskovitz, Y., Chapal-Ilani, N., Mitchell, A., Medeiros, J.J., Biezuner, T., Kaushansky, N., Minden, M.D., Gupta, V. and Milyavsky, M., 2021. Recurrent deletions in clonal hematopoiesis are driven by microhomology-mediated end joining. Nature communications, 12(1), p.2455.
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Gold, A., Eini, L., Nissim-Rafinia, M., Viner, R., Ezer, S., Erez, K., Aqaqe, N., Hanania, R., Milyavsky, M., Meshorer, E. and Goldberg, M., 2019. Spironolactone inhibits the growth of cancer stem cells by impairing DNA damage response. Oncogene, 38(17), pp.3103-3118.​
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Aqaqe, N., Yassin, M., Yassin, A.A., Ershaid, N., Katz-Even, C., Zipin-Roitman, A., Kugler, E., Lechman, E.R., Gan, O.I., Mitchell, A. and Dick, J.E., 2019. An ERG enhancer–based reporter identifies leukemia cells with elevated leukemogenic potential driven by ERG-USP9X feed-forward regulation. Cancer research, 79(15), pp.3862-3876.
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Yassin, M., Aqaqe, N., Yassin, A.A., van Galen, P., Kugler, E., Bernstein, B.E., Koren-Michowitz, M., Canaani, J., Nagler, A., Lechman, E.R. and Dick, J.E., 2019. A novel method for detecting the cellular stemness state in normal and leukemic human hematopoietic cells can predict disease outcome and drug sensitivity. Leukemia, 33(8), pp.2061-2077.
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Biechonski, S., Olender, L., Zipin-Roitman, A., Yassin, M., Aqaqe, N., Marcu-Malina, V., Rall-Scharpf, M., Trottier, M., Meyn, M.S., Wiesmüller, L. and Beider, K., 2018. Attenuated DNA damage responses and increased apoptosis characterize human hematopoietic stem cells exposed to irradiation. Scientific reports, 8(1), p.6071.
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Rall-Scharpf, M., Friedl, T.W., Biechonski, S., Denkinger, M., Milyavsky, M. and Wiesmüller, L., 2021. Sex-specific differences in DNA double-strand break repair of cycling human lymphocytes during aging. Aging (Albany NY), 13(17), p.21066.
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Raz, Y., Cohen, N., Shani, O., Bell, R.E., Novitskiy, S.V., Abramovitz, L., Levy, C., Milyavsky, M., Leider-Trejo, L., Moses, H.L. and Grisaru, D., 2018. Bone marrow–derived fibroblasts are a functionally distinct stromal cell population in breast cancer. Journal of Experimental Medicine, 215(12), pp.3075-3093.
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Flach, J. and Milyavsky, M., 2018. Replication stress in hematopoietic stem cells in mouse and man. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 808, pp.74-82.
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Biechonski, S., Olender, L., Zipin-roitman, A., Yassin, M., Aqaqe, N., Marcu-malina, V., Rall-scharpf, M., Trottier, M., Meyn, M.S., Wiesmüller, L., Beider, K., Raz, Y., Grisaru, D., Nagler, A., Milyavsky, M., 2018. Attenuated DNA damage responses and increased apoptosis characterize human hematopoietic stem cells exposed to irradiation. Sci. Rep 1–13
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Biechonski, S., Gourevich, D., Rall, M., Aqaqe, N., Yassin, M., Zipin-Roitman, A., Trakhtenbrot, L., Olender, L., Raz, Y., Jaffa, A.J., Grisaru, D., Wiesmuller, L., Elad, D., Milyavsky, M., 2017. Quercetin alters the DNA damage response in human hematopoietic stem and progenitor cells via TopoII- and PI3K-dependent mechanisms synergizing in leukemogenic rearrangements. Int. J. Cancer 140, 864–876.
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Zipin-Roitman, A., Aqaqe, N., Yassin, M., Biechonski, S., Amer, M., van Delft, M.F., Gan, O.I., McDermott, S.P., Buzina, A., Ketela, T., Shlush, L., Xie, S., Voisin, V., Moffat, J., Minden, M.D., Dick, J.E., Milyavsky, M., 2017. SMYD2 lysine methyltransferase regulates leukemia cell growth and regeneration after genotoxic stress. Oncotarget 8.
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Louria-Hayon, I., Frelin, C., Ruston, J., Gish, G., Jin, J., Kofler, M.M., Lambert, J.-P., Adissu, H.A., Milyavsky, M., Herrington, R., Minden, M.D., Dick, J.E., Gingras, A.-C., Iscove, N.N., Pawson, T., 2013. Lnk adaptor suppresses radiation resistance and radiation-induced B-cell malignancies by inhibiting IL-11 signaling. Proc. Natl. Acad. Sci. 110, 20599–20604.
Chan, G., Cheung, L.S., Yang, W., Milyavsky, M., Sanders, A.D., Gu, S., Hong, W.X., Liu, A.X., Wang, X., Barbara, M., Sharma, T., Gavin, J., Kutok, J.L., Iscove, N.N., Shannon, K.M., Dick, J.E., Neel, B.G., Braun, B.S., 2011. Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells. Blood 117, 4253–4261.
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Milyavsky, M., Gan, O.I., Trottier, M., Komosa, M., Tabach, O., Notta, F., Lechman, E., Hermans, K.G., Eppert, K., Konovalova, Z., Ornatsky, O., Domany, E., Meyn, M.S., Dick, J.E., 2008. Article A Distinctive DNA Damage Response in Human Hematopoietic Stem Cells Reveals an Apoptosis-Independent Role for p53 in Self-Renewal. Cell Stem Cell 7, 186–197.
Milyavsky, M., Shats, I., Cholostoy, A., Brosh, R., Buganim, Y., Weisz, L., Kogan, I., Cohen, M., Shatz, M., Madar, S., Kalo, E., Goldfinger, N., Yuan, J., Ron, S., Mackenzie, K., Eden, A., Rotter, V., 2007. Article Inactivation of Myocardin and p16 during Malignant Transformation Contributes to a Differentiation Defect. Cancer Cell 133–146.
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Milyavsky, M., Tabach, Y., Shats, I., Erez, N., Cohen, Y., Tang, X., Kalis, M., Kogan, I., Buganim, Y., Goldfinger, N., Ginsberg, D., Harris, C.C., Domany, E., Rotter, V., 2005. Transcriptional Programs following Genetic Alterations in p53 , INK4A , and H-Ras Genes along Defined Stages of Malignant Transformation. Cancer Res. 65, 4530–4544.
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Phenotype, P., Milyavsky, M., Shats, I., Erez, N., Tang, X., Senderovich, S., Meerson, A., Tabach, Y., Goldfinger, N., Ginsberg, D., Harris, C.C., Rotter, V., 2003. Prolonged Culture of Telomerase-Immortalized Human Fibroblasts Leads to a. Cancer Res. 63, 7147–7157.
Milyavsky, M., Mimran, A., Senderovich, S., Zurer, I., Erez, N., Shats, I., Goldfinger, N., Cohen, I., Rotter, V., 2001. Activation of p53 protein by telomeric (TTAGGG)n repeats. Nucleic Acids Res. 29, 5207–15.
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Reviews
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Biechonski, S., Yassin, M., & Milyavsky, M. (2017). DNA-damage response in hematopoietic stem cells: an evolutionary trade-off between blood regeneration and leukemia suppression. Carcinogenesis, 38(4), 367-377.
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Milyavsky, M., Gole, B., & Wiesmüller, L. (2015). Replication stress in MLL-rearrangements. Oncoscience, 2(12), 938.
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Biechonski, S., and M. Milyavsky. 2013. Differences between Human and Rodent DNA-Damage Response in Hematopoietic Stem Cells: at the Crossroads of Self-Renewal, Aging and Leukemogenesis. Translational Cancer Research 2 (6):372-383